Analysis of the effect of liquid viscosity on the aerosol distribution during Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) using computational modeling

Background: Peritoneal metastases (PM) are a common manifestation of gastro-intestinal and gynecological cancers. Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) has been proposed as new drug delivery technique to treat patients with PM. During this procedure, CO2 pneumoperitoneum (12 mmHg) is established. Subsequently, nebulizer (Capnopen®, Zimmern, Germany) aerosolizes the chemotherapy into inflated peritoneal cavity using high-pressure injector (Injektron™ 82 M, Medtron, Saarbrücken, aim obtain homogeneous aerosol droplet distribution. The goal present work was investigate effect liquid viscosity on homogeneity distribution during PIPAC Computational Fluid Dynamics (CFD) modeling.